A protein binds ligand A with a kon (or k1) of 10207136 M-1 s-1. The value of koff (or k2) for this ligand is 0.02 s-1. This same protein binds ligand B with a kon (or k1) of 1024216 M-1 s-1, and the value of koff (or k2) for this ligand is 12 s-1. According to these data, the protein has a greater affinity for ligand A than it has for ligand B. How much greater is this affinity? In other words, by what factor would you have to multiply the value that represents the affinity for ligand B by to equal the value that represents the affinity for ligand A. Report your answer to the nearest ones. You should use all the figures given, but please note that the kon’s are expressed with far more precision than is warranted.
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