Adding groups to outer surface of
drugs for transport
When biomedical researchers design
drugs that must enter cells to be effective, they sometimes add methyl (CH3)
groups all over the outer surface to make the drug molecules more likely to
pass through cell membranes. Conversly,when researchers design drugs that act
on the exterior of cell membranes, they sometimes add a charged group to
decrease the likelihood that the drugs will pass through membranes and enter
cells. Explain why these strategies make sense.
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