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Why is case 2 positive cooperativity and case 3 negative
cooperativity?
Biomolecular System CDK8+Ligand Case1: CyclinC+CDK8+Ligand Case2: CyclinC+CDK8+Ligand Case3: CyclinC+CDK8+Ligand Binding Affinity of Ligand -10 kcal/mol -10 kcal/mol -13 kcal/mol -7 kcal/mol
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