Caption: Relative firefly luciferase assay using promoter regions from DNMT3 from Sinkkonen et. al, (2010) MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat. Struct Mol Biol. Figure 2 Dicer-/- ES cells have reduced levels of DNMT3 expression and the addition of miR-290 actually restores the expression of DNMT3. Propose a mechanism that might explain these phenomena and the purpose for the figure above.