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Question: Instructure-uploads.s3.amazonaws.com d) LeuT is a bacterial homolog of the human neuronal seroton…

by | Dec 3, 2023 | Posted Questions

Question: Instructure-uploads.s3.amazonaws.com d) LeuT is a bacterial homolog of the human neuronal seroton...

instructure-uploads.s3.amazonaws.com d) LeuT is a bacterial homolog of the human neuronal serotonin transporter, targeted by selective serotonin re-uptake inhibitors (SSRI) used as antidepressants. The drug Prozac is a racemic mixture of R-fluoxetine (Kd 0.25 mM) and S-fluoxetine (Kd 400 mM). Do these compounds bind more tightly than the native L-Leu substrate? Based on this information, would you predict that only one enantiomer of Prozac is responsible for the antidepressant function?

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