Please explain the answer to this question!
Consider the following peptide: Ala-Arg-His-Asp-Leu. What is teh
approximate isoelectric point?
Given the following pKa’s:
Alanine: 2.3 and 9.7
Arginine: 2.2, 9.0, and 12.5 (R group)
Histidine: 1.8, 6.0 (Rgroup), and 9.2
Asparte: 1.9, 3.7 (Rgroup), and 9.6
Leucine: 2.4 and 9.6
“Answer is: 7.8”





