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Shown here is a PKU-causing mutation in the gene encoding phenylalanine hydroxylase. Classify the mutation and describe the probable effect on enzyme activity. Also, indicate the two different one-base-pair changes that could have occurred in the coding (non-template) strand of the DNA. Which change would you consider the biochemically “easier”?
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Question: Shown here is a PKU-causing mutation in the gene encoding phenylalanine hydroxylase. Classify the…
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