Virulence genes in the pathogen Staphylococcus aureus
are activated only when the cell density reaches a threshold.
Explain how does S. aureus sense its cell density to
activate gene expression. Based on this knowledge, discuss how
antibacterial drugs can be designed to disrupt virulence gene
activation and what are the potential advantages of using these
drugs rather than using antibiotics to treat S. aureus
infection.
I said: The expression of virulence in pathogenic bacteria is
controlled by quorum sensing. Quorum sensing is a cell to cell
communication among bacterial populations to adjust gene expression
based on cell density. based on the slides but need help with a
more complete answer.
QS circuits in Gram-positive bacteria ·DNA transformation: transoca some (transformasome). Signal molecule: competent factor (CF)-a short peptide. CF is secreted out through an export complex. The accumulation of CF in the environment is sensed by a two component regulatory system. Phosphorylated response regulator (RR) induces transcription. Cytoplasmic PeptidoglycanRJTranslocasome DNA fragment membrane cell wall ComA ComC Competence factor export ComE 0 Competence factor action Sp
ScholarMatic: Explanation & Answer
Your ready answer from a verified tutor is just a click away for as little as $14.99
Click Order Now to get 100% Original Answer Customized to your instructions!
